Eddy Curry couldn't, that's for sure, hahahaha!
Look at the end of this video, Cousins handles the ball from his own court and finishes with a nice pass to Patterson on the other end:
How about this:
at 1:20- DC handles the ball in transition, attacks the rim and finishes with the no look pass.
at 1:45 DC steals the ball midcourt and goes all the way to the basket.
This kid's ballhandling skills are PHENOMENAL for a guy that big. That's one of the reasons why I think he could play PF on O. His skill set allows him to be a superior player to someone like Favors when facing the basket. Not only the ball handling skills, it's also the ability to put the ball on the floor and his superior mid range game.